An anti-human T-cell immunoglobulin domain and mucin domain 3 (TIM-3) antibody, can bind the peptides, comprising the amino-acid sequence RKGDVSL (SEQ ID NO: 9) and/or EKFNLKL (SEQ ID NO: 10) of human TIM-3 protein. The antibody can regulate immune cell activity. The antibody or binding fragment thereof is useful in diagnosis, prognosis, and treatment of cancers that have been reported to express cell-surface TIM-3 such as lung, liver, esophageal cancer and solid tumors.本發明係關於一種抗人類T細胞免疫球蛋白結構域及黏蛋白結構域3 (TIM-3)抗體,該抗體可結合包含人類TIM-3蛋白之胺基酸序列RKGDVSL (SEQ ID NO: 9)及/或EKFNLKL (SEQ ID NO: 10)之肽。該抗體可調節免疫細胞活性。該抗體或其結合片段可用於據報導可表現細胞表面TIM-3之癌症的診斷、預後及治療,諸如肺癌、肝癌、食道癌及固態腫瘤。
