Antibodies specific to pyroglutamated Aβ

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专利权人:

H. Lundbeck A/S

发明人:

Søren Christensen,Lone Helboe

申请号：

US15288476

公开号：

US10472414B2

申请日:

2016.10.07

申请国别(地区):

US

年份:

2019

代理人:

摘要：

The present invention relates to antibodies specific for pyroglutamated Aβ, as well as their use in the treatment of Alzheimer's disease and as use in diagnostic methods or as diagnostic imaging ligands. Further, is provided pyroglutamated N-terminal fragments of murine or human Aβ to generate antibodies and for use in therapeutic purposes.

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