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REDUCTION OF LIPASE ACTIVITY IN PRODUCT FORMULATIONS
专利权人:
Yatin Gokarn;Nick Levy;Kelvin LEE;Kristin Valente;Abraham Lenhoff
发明人:
Kelvin LEE,Abraham Lenhoff,Kristin Valente,Nick Levy,Yatin Gokarn
申请号:
US16565606
公开号:
US20190390203A1
申请日:
2019.09.10
申请国别(地区):
US
年份:
2019
代理人:
摘要:
The invention relates a method for producing a stable recombinant protein, comprising growing a non-naturally occurring host cell in a culture medium to produce a recombinant protein, and making a composition comprising the recombinant protein and a polysorbate. The production of endogenous lipoprotein lipase by the host cell is reduced. The endogenous lipoprotein lipase is present in the composition in a small amount, and is capable of degrading the polysorbate. The invention also relates to the relevant host cells and compositions, and preparation thereof.
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