Provided is a novel treatment strategy for anti-PD-1 antibody treatment. A pharmaceutical composition including at least one substance selected from the group consisting of (i)-(iii) below, administered before, after, or simultaneously with administration of a PD-1 signal inhibitor. (i) ROS generators and substances that control downstream signals thereof, (ii) substances exhibiting an uncoupling effect and substances that control downstream signals thereof, and (iii) amino acids.本發明提供一種抗PD-1抗體治療之新穎治療戰略。一種醫藥組合物，其包含選自由下述(i)至(iii)所組成之群中之至少1種物質，且於投予PD-1訊息抑制劑之前、之後或同時之任一時期進行投予：(i)ROS產生劑及控制其下游訊息之物質、(ii)顯示出解偶聯作用之物質及控制其下游訊息之物質、以及(iii)胺基酸。
