Provided is a targeted drug delivery device for antitumor magnetic nanoparticle drugs including a transfusion container for accommodating antitumor magnetic nanoparticle drugs and a drug solution conveying device connected to the transfusion container and used for conveying the antitumor magnetic nanoparticle drugs. A magnetic field generating device capable of producing magnetic adsorption to the antitumor magnetic nanoparticle drug and a bioelectric sensor for sensing the response of living tissues in a tumor region to magnetic stimulation are arranged at an external position of the human body corresponding to the tumor region. The targeted drug delivery device is provided with a control unit for receiving and analyzing signals of the bioelectric sensor and providing a master control on the required magnetic field intensity, transfusion speed and liquid flow according to the signals of the bioelectric sensor.