DR SARBANI HAZRA,DR UDAY B KOMPELLA,RUCHIT TRIVEDI
申请号：
IN232/KOL/2013
公开号：
IN2013KO00232A
申请日:
2013.02.28
申请国别(地区):
IN
年份:
2014
代理人:
摘要：
This invention relates to a Pirfenidone composition includingpirfenidone loaded polymeric (e.g., poly lactide-co-glycolide(PLGA) nanoparticles), pirfenidonenano emulsion, and pirfenidonenano suspensionsfor eye drop administration. This invention also relates to a Pirfenidone composition in which pirfenidone nanoparticles but not free pirfenidone significantly (P<0.05) reduced corneal haze as well as the time for corneal re-epithelialization following alkali burn, thereby improving corneal wound healing. More particularly, this present invention relates to Pirfenidone composition containing Pirfenidonenano dosage form toprevent fibrosis and Pirfenidone nanoparticles are of potential therapeutic value in treating corneal injuries, other corneal fibrotic diseases, as well as other ocular diseases associated with injury, inflammation, and firbrosis.
