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Bisarilsulfonamides useful in the treatment of inflammation and cancer
专利权人:
Kancera AB
发明人:
MARTINSSON, Jessica,FÄRNEGÅRDH, Katarina,JÖNSSON, Mattias,RINGOM, Rune
申请号:
ES12806515
公开号:
ES2649116T3
申请日:
2012.12.21
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
A compound of formula (I) ** Formula ** wherein n is 0 or 1; A is O, S, -CR4>; = CR4- or -CR4>; = N-; R1 is selected from H; halogen; C1-C6 alkyl, optionally substituted with at least one halogen; and C1-C6 alkoxy, optionally substituted with at least one halogen; each of R2 and R3 is independently selected from H; halogen; C1-C6 alkyl; C1-C6 alkoxy; carbamoyl; secondary or tertiary C1-C6 alkylamide; carbocyclylcarbonylamino-C0-C2 alkyl; 5 or 6-membered cyclic aminocarbonyl optionally containing an additional ring heteroatom; C1-C6 alkylcarbonylamino; C1-C6 alkylsulfonyl; hydroxy-C0-C6 alkyl, C1-C6 alkylcarbonyl; carboxy; C1-C6 alkoxycarbonyl; cyano; carbocyclyloxy; heterocyclyloxy; carbocyclyl-C0-C3 alkyl; C2-C3 carbocyclyl-alkenyl; heterocyclyl-C0-C3 alkyl; and C2-C3 heterocyclyl-alkenyl; wherein any alkyl is optionally substituted with at least one halogen; any carbocyclyl or heterocyclyl is 5 or 6 membered monocyclyl or 9 or 10 membered bicyclyl; and any carbocyclyl or heterocyclyl is optionally substituted with at least one R5; or R2 and R3 form, together with the carbon atoms to which they are attached, a 5- or 6-membered carbocyclic or heterocyclic ring, the ring of which is optionally substituted with at least one R5; with the proviso that R1, R2 and R3 are not hydrogen; each R4 is independently selected from H, halogen, monocyclic C3-C6 carbocyclyl and C1-C6 alkyl, wherein any alkyl is optionally substituted with at least one halogen; each R5 is independently selected from halogen; C1-C6 alkyl; C1-C6 alkoxy; phenoxy; Not me; cyano; nitro; secondary or tertiary C1-C6 alkylamino; 5 or 6-membered cyclic amino, optionally containing at least one additional ring heteroatom; C1-C6 alkylcarbonylamino; carbamoyl; secondary or tertiary C1-C6 alkylamide; 5- or 6-membered cyclic aminocarbonyl; C1-C6 alkoxycarbonylamino; hydroxy-C0-C6 alkyl; C1-C6 alkylthio; C0-C6 carboxy-alkyl; C1-C6 alkoxycarbonyl; C1-C6 alkylcarbonyl; C1-C6 alkylsulfonyl; and C1-C6 alkylsulfonyl
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