ZHONG SUJU,WALLACE CRAIG,BRYANT SHAUGHN H.,MCRAE BRADFORD L.,TARCSA EDIT,CLABBERS ANCA,KUTSKOVA YULIYA,LEDDY MARY R.,MEMMOTT JOHN E.,MURTAZA ANWAR,HSIEH CHUNG-MING,PEREZ JENNIFER M.,HUGUNIN MARGARET
申请号：
NZ61132410
公开号：
NZ611324A
申请日:
2010.03.05
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
A binding protein capable of binding human IL-17 and TNF-a comprising first and second polypeptide chains, wherein the first polypeptide chain comprises a first VD1- (X1)n-VD2-C-(X2)n, wherein VD1 is a first heavy chain variable domain； VD2 is a second heavy chain variable domain； C is a heavy chain constant domain； X1 is a linker with the proviso that it is not CH1； X2 is an Fc region； n is 0 or 1； and wherein the second polypeptide chain comprises a second VD1-(X1)n-VD2-C-(X2)n, wherein VD1 is a first light chain variable domain； VD2 is a second light chain variable domain； C is a light chain constant domain； X1 is a linker with the proviso that it is not CH1； X2 does not comprise an Fc region； n is 0 or 1； and wherein, in the first polypeptide chain, the VD1 or VD2 heavy chain variable domains comprise an amino acid sequence selected from the group consisting of SEQ ID NOs: 565, 670, 720, 740, 845, and 875； and wherein, in the second polypeptide chain, the VD1 or VD2 light chain variable domains comprise an amino acid sequence selected from the group consisting of SEQ ID NOs: 570, 675, 725, 745, 850, and 880.
