The invention provides a stable water pharmacological formula, which includes anti PDL1 antibody, histidine acetate or sodium acetate, sucrose and polyurethane. The invention also provides a method for the design and use of the formulaLa invencion proporciona formulaciones farmaceuticas acuosas estables que comprenden un anticuerpo anti-PDL1, acetato de histidina o acetato de sodio, sacarosa, polisorbato. La invencion tambien proporciona metodos para preparar tales formulaciones y metodos de uso de tales formulaciones