A negative pressure wound dressing is provided. The negative pressure wound dressing sequentially includes a backing layer, a water blocking layer, an absorbent layer and a wound contacting layer. Wherein, the backing layer includes a connecting aperture for fluidly communicating to a negative pressure source. The wound contacting layer includes a surface layer for wound contacting and a plurality of chambers containing a medication, wherein openings of the chambers are disposed on the surface layer for releasing the medication contained in the chamber. The medication can be prevented from being suctioned to the absorbent layer and can be released toward the wound to enhance the wound healing by using the negative pressure wound dressing.
