A medical fluid delivery system for the use in the delivery of medical fluids.The medical fluid delivery system may include a pumping system, a disposablemedical fluid line set and a valve operating system. The disposable tubing lineset may include valves adapted to interface with the valve operating system.The valve operating system may be adapted to operate only selected valves usinga single drive means. The pumping system may be operated over a wide range of medicalfluid delivery rates by employing a bi-directional drive member and a transmissioninterfaced with the drive member and a pump.