Siva Ram Kiran Vaka,Paras Jariwala,Jaydeep Vaghashiya,Atsawin Thongsukmak,Dipen Desai,Wantanee Phuapradit,Navnit H. Shah
申请号：
US16809714
公开号：
US20200253861A1
申请日:
2020.03.05
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present disclosure provides programmable osmotic-controlled oral compositions providing delayed release of a therapeutically acceptable amount of a drug. The programmable osmotic-controlled compositions of the disclosure provide a lag time that is independent of the presence or absence of food, type of food, pH, gastric emptying, gastric motility, and volume and viscosity of gastric fluid. The compositions of the disclosure can be programmed to provide a desired and precise lag time, and release drug, after the lag time, at a rhythm, e.g., that matches the human circadian rhythm of a condition's symptoms and/or of the individual being treated in the application of the therapy to optimize therapeutic outcome and minimize side effects.
