A method for producing a microneedle device which comprises a coating on microneedles. This method for producing a microneedle device comprises: a step A wherein a freeze-dried composition is obtained by drying a precursor composition that contains a biologically active substance and a first solvent； a step B wherein a coating composition is obtained by mixing the freeze-dried composition and a second solvent with each other； and a step C wherein the coating composition is applied to the microneedles and then dried. In this method, the precursor composition additionally contains a thickening agent, or alternatively, a thickening agent is added when the freeze-dried composition and the second solvent are mixed with each other.本發明係一種微針裝置之製造方法，其係製造於微針上具備塗層之微針裝置之方法，且包括：步驟A，其將含有生理活性物質及第1溶劑之前驅組合物乾燥，而獲得冷凍乾燥組合物；步驟B，其將上述冷凍乾燥組合物及第2溶劑混合，而獲得塗層組合物；及步驟C，其將上述塗層組合物塗佈於上述微針，並進行乾燥；上述前驅組合物進而含有增黏劑，或於將上述冷凍乾燥組合物及第2溶劑混合時添加增黏劑。
