CRIBLAGE FONCTIONNEL DE POLYPEPTIDES ANTIGÉNIQUES - UTILISATION POUR L'IDENTIFICATION D'ANTIGÈNES ÉLICITANT UNE RÉPONSE IMMUNITAIRE PROTECTRICE ET POUR LA SÉLECTION D'ANTIGÈNES PRÉSENTANT UNE ACTIVITÉ DE PROTECTION OPTIMALE
The invention is in the field of functional screening of protective antigens against pathogens in particular against pathogens such as parasites, bacteria, viruses or protective antigens of cancer cells in order to identify antigens suitable for the elicitation of a protective immune response in a host, and/or to optimize antigen design, in particular to define suitable antigen combinations for a protective immune response. The invention thus involves using a lentiviral vaccine platform for induction of a specific cellular or humoral response against assayed antigens on one hand, and using a fast and reproducible assay for the evaluation of the induced protective effect after challenge.
