Compositions comprising various fatty acids and their variants such as DHA, DHA-lysoPC, and EPA combined with neuro-therapeutic metal ions such as magnesium (Mg), zinc (Zn) or lithium (Li), capable of traversing the blood-brain barrier (“BBB), and blood nerve barrier (“BNB”) and methods of use of such compositions to provide therapeutic concentrations of Mg, Zn, or Li in cerebrospinal fluid over a desired period of time to a subject presenting symptoms of Mg, Zn, or Li deficiency or disease symptoms which are alleviated by supplementation of such ions are provided These symptoms may include, but are not limited to, mild cognitive impairment, bipolar disorder, stroke, and pain.
