Coprocessed compositions containing calcium phosphate and microcrystalline cellulose are useful as excipients in the preparation of solid dosage forms containing active pharmaceutical ingredients, particularly those prepared by processes involving multiple compaction steps. Such compositions may be obtained by preparing aqueous slurries of microcrystalline cellulose and calcium phosphate and drying such slurries to produce particulate products. The coprocessed products exhibit improved compactibility, as compared to dry physical blends of the same components.本發明係關於含有磷酸鈣及微晶纖維素之共同加工組合物,其可作為賦形劑用於製備含有活性醫藥成分之固體劑型,尤其藉由涉及多個壓實步驟之方法製備之固體劑型。該等組合物可藉由製備微晶纖維素及磷酸鈣之含水漿料且乾燥該等漿料以產生微粒產物來獲得。與相同組分之乾燥物理摻合物相比,該等共同加工產物展現經改良之壓實性。(無元件符號說明)
