MEMORIAL SLOAN KETTERING CANCER CENTER;ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
发明人:
ZAMARIN DMITRIY,WOLCHOK JEDD D,ALLISON JAMES
申请号：
AP201508685
公开号：
AP201508685A0
申请日:
2014.03.04
申请国别(地区):
AP
年份:
2015
代理人:
摘要：
Described herein are chimeric Newcastle disease viruses engineered to express an agonist of a co-stimulatory signal of an immune cell and compositions comprising such viruses. Also described herein are chimeric Newcastle disease viruses engineered to express an antagonist of an inhibitory signal of an immune cell and compositions comprising such viruses. The chimeric Newcastle disease viruses and compositions are useful in the treatment of cancer. In addition, described herein are methods for treating cancer comprising administering Newcastle disease viruses in combination with an agonist of a co-stimulatory signal of an immune and/or an antagonist of an inhibitory signal of an immune cell.
