Compounds and compositions for the treatment of bone disorders are presented. Oxysterol compounds and compositions for the treatment of bone disorders are presented. The compounds are conjugates or derivatives of (3S 5S 6S 8R 9S 10R 13S 14S 17S) 17 [(2S) 2 hydroxyoctan 2 yl] 10 13 dimethyl 2 3 4 5 6 7 8 9 11 12 14 15 16 17 tetradecahydro 1H cyclopenta[a]phenanthrene 3 6 diol with a BTA linker such as from a tetracycline fragment attached to 3 position 6 position or 20 position. These osteogenic oxysterol compounds stimulate hedgehog signaling pathway. The various linker units are susceptible to certain esterases.
