BAETTIG, URS,BALA, KAMLESH JAGDIS,BUDD, EMMA,EDWARDS, LEE,HOWSHAM, CATHERINE,HUGHES, GLYN,LEGRAND, DARREN MARK,SPIEGEL, KATRIN
申请号：
PE0015662012
公开号：
PE03432013A1
申请日:
2011.03.17
申请国别(地区):
PE
年份:
2013
代理人:
摘要：
Refers to a compound of formula (i) where a is n or cr4a, ra is H or alkyl of C1 - C4, R1 is H, alkyl, optionally substituted by Halogen C1 C8, alquinilo alquinilo, among others R2 is alkyl of C1 - C4 - Halo R3 is H or alkyl of C1 - C8 Optionally substituted R4 is H, alkyl of C1 C8 - optional Easily replaced R5 is - (CH2) M - nr17r18 alkoxyl of C1, C8, among others, R17 and R18 is H,C1 C8 alkyl, optionally substituted, M is 0, 1, 2 or 3 R6 C1 C8 alkyl, optionally substituted by Halogen Atoms alkyl, cycloalkyl, among others.Preferred compounds are () - trifluoro - 2 - hydroxy - 2 - Methyl Propyl) - amide amino acid 3 - (4 - 6 - 5 - fluoro - phenyl) - pyridin - trifluoro methyl - 2 - 3 - amino - acid, 6 - (pyrrolidin-1-yl) - N - () - trifluoro - 2 - hydroxy - 2 - Methyl Propyl) - 5 - (trifluoro methyl) - picolinamida, among others. It also relates to a Pharmaceutical composition.These compounds enhance the function of cystic fibrosis transmembrane conductance regulator (CFTR) Mutant and \/ or wild type to be useful for the treatment of cystic fibrosis.SE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE: A ES N O CR4A, RA ES H O ALQUILO DE C1-C4, R1 ES H, ALQUILO C1-C8 OPCIONALMENTE SUSTITUIDO POR HALOGENO, ALQUINILO, ALQUINILO ENTRE OTROS R2 ES HALO-ALQUILO DE C1-C4 R3 ES H O ALQUILO C1-C8 OPCIONALMENTE SUSTITUIDO R4 ES H, ALQUILO DE C1-C8 OPCIONALMENTE SUSTITUIDO R5 ES -(CH2)m -NR17R18 , ALCOXILO DE C1-C8, ENTRE OTROS, DONDE R17 Y R18 ES H, ALQUILO C1-C8 OPCIONALMENTE SUSTITUIDO, m ES 0, 1, 2 O 3 R6 ES ALQUILO DE C1-C8 OPCIONALMENTE SUSTITUIDO POR ATOMOS DE HALOGENO CICLOALQUILO, ALQUILO ENTRE OTROS. SON COMPUESTOS PREFERIDOS (3,3,3-TRIFLUORO-2-HIDROXI-2-METIL-PROPIL)-AMIDA DEL ACIDO 3-AMINO-6-(4-FLUORO-FENIL)-5-TRIFLUORO-METIL-PIRIDIN-2-CARBOXILICO, 3-AMINO-6-(PIRROLIDIN-1-IL)-N-(3,3,3-TRIFLUORO-2-HIDROXI-2-METIL-PROPIL)-5-(TRIFLUORO-METIL)-PICOLINAMIDA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS MEJORAN LA FUNCION DEL REGULADOR DE
