Jeffry B. Stock;Joel Gordon;Eduardo Perez;Seung-Yub Lee;Maxwell Stock;Keshava Rapole;Michael Voronkov;Shuyi Chen
发明人:
Jeffry B. Stock,Maxwell Stock,Keshava Rapole,Seung-Yub Lee,Michael Voronkov,Eduardo Perez,Joel Gordon,Shuyi Chen
申请号：
US13566839
公开号：
US20120328540A1
申请日:
2012.08.03
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Among other things, the present invention provides novel compounds capable of effectively inhibiting inflammatory responses that are mediated by G-proteins or GPCRs in neutrophils, macrophages and platelets. In particular, the compounds of the present invention act as inhibitors of edema, inhibitors of erythema and inhibitors of MPO (myeloperoxidase), pharmaceutical compositions containing the same compounds and the use thereof for the treatment of diseases that may benefit from edema, erythema and MPO inhibition, such as inflammation (acute or chronic), asthma, autoimmune diseases, and chronic obstructive pulmonary disease (COPD) (e.g., emphysema, chronic bronchitis and small airways disease, etc.), inflammatory responses of the immune system, skin diseases (e.g., reducing acute skin irritation for patients suffering from rosacea, atopic dermatitis, seborrheic dermatitis, psoriasis), irritable bowel syndrome (e.g., Chron's disease and ulcerative colitis, etc.), and central nervous system disorders (e.g., Parkinson's disease).
