NOVEL CRYSTALLINE FORM OF 5-CHLORO-N-({(5S)-2-OXO-3-[4-(5,6-DIHYDRO-4H-[1,2,4]TRIAZIN-1-YL)PHENYL]-1,3-OXAZOLIDIN-5-YL}METHYL)THIOPHENE-2-CARBOXAMIDE METHANESULFONATE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
The present invention relates to a novel crystalline form of 5-chloro-N-({(5S)-2-oxo-3-[4-(5,6-dihydro-4H-[1,2,4]triazin-1-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide methanesulfonate and a pharmaceutical composition containing the same. The novel crystalline form of a compound according to the present invention exhibits excellent stability even in high-temperature and humidity environments, and thus can be favorably used to prevent or treat diseases, such as thrombosis, myocardial infarction, atherosclerosis, inflammation, stroke, angina pectoris, restenosis after angioplasty, and thromboembolism.La présente invention concerne une nouvelle forme cristalline de méthanesulfonate de 5-chloro-N-({(5S)-2-oxo-3-[4-(5,6-dihydro-4H-[1,2,4]triazin-1-yl)phényl]-1,3-oxazolidin-5-yl}méthyl)thiophène-2-carboxamide et une composition pharmaceutique le contenant. La nouvelle forme cristalline dun composé selon la présente invention présente une excellente stabilité, même dans des environnements à haute température et haute humidité et peut donc être utilisée favorablement pour prévenir ou traiter des maladies, telles quune thrombose, un infarctus du myocarde, lathérosclérose, une inflammation, un AVC, une angine de poitrine, une resténose après angioplastie et la thromboembolie.본 발명은 5-클로로 -N -({ (5 S)-2-옥소-3- [4-(5, 6-디하이드로 -4H- [ 1, 2, 4]트리아진-1-일)페닐] -1, 3-옥사졸리딘 -5-일 }메틸)티오펜-2-카르복사미드 메탄설폰산염의 신규 결정형 및 이를 포함하는 약학 조성물에 관한 것으로서, 본 발명에 따른 신규 결정형 화합물은 고온 및 가습 환경에서도 우수한 안정성을 나타내므로, 혈전증, 심근 경색, 동맥경화, 염증, 뇌졸중, 협심증, 혈관 성형술 후의 재발협착증 및 혈전색전증 등의 질환의 예방 또는 치료에 유용하게 사용될 수 있다.
