Fa-Xiang Ding,Shuzhi Dong,Jinlong Jiang,Takao Suzuki,Joseph P. Vacca,Shouning Xu
申请号：
US15505620
公开号：
US20170283416A1
申请日:
2015.10.26
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.
