Spontaneously eye diseased condition, especially high eye pressure and/or offer of the model animal which displays retina denaturation is designated as purpose. As for this invention the Vav2 gene and/or it regards the non human animal for the eye diseased model which deficiency it could point function of the Vav3 gene. It can utilize the particular animal, from the fact that eye diseased condition such as high eye pressure and/or retina denaturation is displayed naturally emergence without placing in the dosage and special growth environment of the medicine, as the useful model of elucidation and eye diseased remedy appraisal of eye diseased emergence mechanism. In case of these utilization, because there are no times when influence of the imported sex factor which is prescribed in order until recently artificially to induce the eye disease is received we reflect the natural sick condition, clinical and industrial usefulness are high.自然発生的に眼疾患症状、特に高眼圧及び/又は網膜変性を呈するモデル動物の提供を目的とする。本発明はVav2遺伝子及び/又はVav3遺伝子の機能を欠損させた眼疾患モデル用非ヒト動物に関する。当該動物は、薬物の投与や特殊な生育環境に置くことなく、自然発症的に高眼圧及び/又は網膜変性等の眼疾患症状を呈することから、眼疾患発症機構の解明や眼疾患治療薬評価の有用なモデルとして利用できる。これらの利用の場合、従来人為的に眼疾患を誘発するために投与される外来性因子の影響を受けることがないため自然病態を反映しており、臨床的また産業的な有用性が高い。
