PURPOSE: A linezolid acid addition salt of a novel crystalline type and a linezolid cocrystal are provided to improve stability at high temperature and high solubility.CONSTITUTION: A crystalline type of linezolid acid addition salt contains linezolide fluorate, linezolid bromated, linezolid iodate, and 1,2-ethandisolufonate. The crystalline type is a cocrystal of linezolid with alkyl carboxylic acid of propionic acid, lactic acid, maleic acid. The linezolid fluorate has a crystalline structure of specific peak at angles of diffraction of 13.96, 18.26, 19.18, 23.04, 23.77, 25.42, 27.22 and 30.51 and has a melting point at 180°C. The linezolid bromated has a crystalline structure of specific peak at angles of diffraction of 13.45, 15.70, 17.51, 17.79, 21.73, 22.72, 23.35, 24.42, 25.28, 26.85, 27.52 and 30.13 and has a melting point at 189°C-217°C.COPYRIGHT KIPO 2012본 발명에 따른 신규 결정형의 리네졸리드 산 부가염 및 리네졸리드 공결정은, 고온에서도 안정하고, 종래 리네졸리드의 결정형들에 비해 융점이 높고, 용해도가 우수하므로 의약품 원료로서 우수한 제제학적 특징을 갖는다.
