A system and method for generating a pacing vector selection table senses a heart sound signal generated by a heart sound sensor and representing sounds generated by the heart of the patient. A processor controls the sequential selection of a pacing electrode vectors from electrodes positioned along a heart chamber. Pacing pulses are delivered via the sequentially selected plurality of pacing electrode vectors. The processor receives the heart sound signal, determines a plurality of different pacing responses using the heart sound signal for each of the of pacing electrode vectors, and generates a pacing vector selection table listing the plurality of different pacing responses for each of the plurality of pacing electrode vectors.
