It discloses composition and method can be used for improving transdermal drug nanoparticle. The composition can be it is hydrophobic, and including hydrophobic carrier, volatile silicone fluid and medicament nano granule. The nanoparticle for inhibiting the drug of growing method is also disclosed in aqueous carrier or hydrophobic carrier. In addition, the method for local treatment psoriasis is disclosed using the taxol or other taxanes of the composition containing nanoparticle.