OH, DONG JOONKR,오동준,YOO, JI SEOKKR,유지석,SHIN, DAE HEEKR,신대희,RYOO, BYUNG HWANKR,류병환
申请号：
KR1020130121001
公开号：
KR1020150042408A
申请日:
2013.10.11
申请国别(地区):
KR
年份:
2015
代理人:
摘要：
The present invention relates to a novel pharmaceutical composition whose drug release is regulated to be constant and stable in relation to sustained release pharmaceutical composition including acetaminophen and tramadol. Provided is a sustained release pharmaceutical composition, which includes first sustained release granules including acetaminophen and tramadol and an immediate tramadol release part, wherein acetaminophen controls the release of tramadol. When the composition is injected one time in an empty stomach and after high fat diet, 4,400-7,000 ng/mL of maximum blood acetaminophen concentration on average is provided during average 0.5-3 hours after injection, and 150-250 ng/mL of maximum blood tramadol concentration on average is provided during average 1.5-5 hours after injection.COPYRIGHT KIPO 2015아세트아미노펜 및 트라마돌을 포함하는 제 1서방과립 및트라마돌의 속방부를 포함하며, 상기 아세트아미노펜은 트라마돌의 방출을 제어하며, 상기 조성물을 공복상태 및 고지방식 후 단회투여 했을 때 투여 후 평균 0.5 내지 3시간대까지에서 4,400~7,000ng/mL의 아세트아미노펜의 평균 최대혈중농도를 제공하고, 투여 후 평균 1.5 내지 5시간대까지에서 150~250ng/mL의 트라마돌의 평균 최대혈중농도를 제공하는 것을 특징으로 하는 서방성 약제학적 조성물이 제공된다.
