A medical device for the treatment of papilloma virus (HPV) skin infections is the object of this invention in particular for the treatment of warts and related pathologies. In particular this invention relates to acetylsalicylic acid for use in the topical treatment of HPV skin infections in particular benign infections and more in particular warts. Acetylsalicylic acid may be administered by plaster or patch both in a solid state such as a tablet powder or granulate and by a hydrophilic or hydrophobic gel.