The present invention relates generally to the field of molecular biology and discloses a method for enhancing various economically important yield-related traits in plants. More specifically, the present invention discloses a method for enhancing yield-related traits in plants by modulating expression in a plant of a nucleic acid encoding a CYP704-like (Cytochrome P450 family 704) polypeptide, a DUF1218 polypeptide, a translin-like polypeptide, or an ERG28-like polypeptide. The present invention also discloses plants having modulated expression of a nucleic acid encoding a CYP704-like (Cytochrome P450 family 704) polypeptide, a DUF1218 polypeptide, a translin-like polypeptide, or an ERG28-like polypeptide, which plants have enhanced yield-related traits relative to control plants. The invention also provides hitherto unknown DUF1218 polypeptide-encoding nucleic acids, and constructs comprising the same, useful in performing the methods of the invention.
