A cassette for operatively connecting administration set tubing to an infusion pump includes a thumb tab having a thumb surface, and a tubing connector having an in-line occluder spaced laterally from the thumb tab. The cassette is configured such that a user's hand will cradle the cassette by pressing a thumb of the user's hand against the thumb surface and wrapping at least one finger of the user's hand around and under the thumb tab, whereby a user may apply pressure to tubing connected to the tubing connector at a location corresponding to the in-line occluder in a direction generally opposite to a direction in which the thumb is pressed against the thumb surface, thereby bypassing the in-line occluder and allowing flow through the tubing.
