Disclosed herein are antibody-conjugates and locked nucleic acid-modified oligonucleotides for modulating expression of one or more genes involved in one or more diseases. Compositions and kits comprising antibody-conjugates and/or locked nucleic acid- modified oligonucleotides for modulating expression of one or more genes involved in one or more diseases are disclosed. Methods of preventing and/or treating one or more diseases in a subject by modulating expression of one more genes by contacting cells and/or administering the compositions and kits to the subject are also disclosed.