To provide methods of transdermally absorbing a hydrophilic drug that is intended to increase not only feeling of use but also the percutaneous absorption properties, by using a low molecule gelling agent.SOLUTION: Provided is a method of transdermally absorbing a hydrophilic drug, characterized by using a lipid peptide type compound consisting of at least one of a compound represented by the formula (1) and an analogue compound thereof or a pharmaceutically usable salt thereof. (Where, Rrepresents an aliphatic group of C9-23； Rrepresents H, or an alkyl group of C1 to C4 which may have a branched chain of C1 to 2； Rrepresents -(CH)-X group, n represents a number of 1-4, and X represents an amino group, a guanidino group, a -CONHgroup, or a 5- or 6-membered ring which may have 1 to 3 N or a fused heterocyclic ring composed of a 5-membered ring and a 6-membered ring.)SELECTED DRAWING: None【課題】低分子ゲル化剤を用い、使用感のみならず経皮吸収性の向上を図った親水性薬物を経皮吸収させる方法の提供。【解決手段】式（１）で表される化合物並びにその類似化合物又はその薬学的に使用可能な塩のうちの少なくとも一種からなる脂質ペプチド型化合物を用いることを特徴とする、親水性薬物を経皮吸収させる方法。（式中、Ｒ１はＣ９～２３の脂肪族基、Ｒ２はＨ、又はＣ１～２の分枝鎖を有し得るＣ１～４のアルキル基、Ｒ３は－（ＣＨ２）ｎ－Ｘ基、ｎは１～４の数、Ｘはアミノ基、グアニジノ基、－ＣＯＮＨ２基、又はＮを１～３個有し得る５員環若しくは６員環又は５員環と６員環から構成される縮合複素環を表す。）【選択図】なし
