Consejo Nacional De Investigaciones Cientificas Y Tecnicas (Conicet);Inserm(Institut National De La Sante Et De La Recherche Medicale)
发明人:
David KLATZMANN,Eliane Piaggio,Hugo Lujan
申请号：
US13843766
公开号：
US20140011739A1
申请日:
2013.03.15
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The invention provides compositions for oral delivery and methods of treatment using VSP carriers, such as Giardia sp. variable surface proteins (VSP), to deliver therapeutic agents. VSP drug carriers can be combined with bioactive peptides, e.g., insulin, glucagon, or hGH, and be administered orally or mucosally. VSP carriers are resistant to acidic pHs and to proteolytic degradation and protect therapeutic agents from degradation in the gastrointestinal tract.
