#$%^&*AU2012203291A120120621.pdf#####ABSTRACT A heart valve prosthesis is provided having a selfexpanding multi-level frame that supports a valve body comprising a skirt and plurality of coapting leaflets. The 5 frame transitions between a contracted delivery configuration that enables percutaneous transluminal delivery, and an expanded deployed configuration having an asymmetric hourglass shape. The valve body skirt and leaflets are constructed so that the center of coaptation may be selected 10 to reduce horizontal forces applied to the commissures of the valve, and to efficiently distribute and transmit forces along the leaflets and to the frame. Alternatively, the valve body may be used as a surgically implantable replacement valve prosthesis.1/5 10 FIG.1A 12 17J DC 14 23 12 168 b1 --- z1Z2 26 25 1g 24 FIG.1B 20 22 20 22 ,24 FIG.1C
