Providing an implantable and refillable drug sustained release device that achieves drug delivery with controllable drug release rate at a desired release rate over an extended period of time of several months or more. A box-shaped polydimethylsiloxane (PDMS) reservoir capable of encapsulating a drug, which is a sustained drug sustained-release device that can be re-injected using a syringe in a state of being implanted in the body, for implantation in the body A sustained drug sustained release device capable of reinjecting a drug, comprising a lid of PDMS sheet and a sustained release surface having a pore.数か月以上の長期間にわたり、希望の放出速度で薬物放出速度を制御可能な薬物送達を達成する、埋植可能かつ再充填可能な薬物徐放デバイスの提供。 体内に移植するための、体内に移植した状態でシリンジを用いて薬物を再注入可能な持続性薬物徐放デバイスであって、薬物を内包させることができる箱状のポリジメチルシロキサン（ＰＤＭＳ）リザーバーとＰＤＭＳシートの蓋を含み、ポアを有する徐放面を有する、薬物を再注入可能な持続性薬物徐放デバイス。
