METHYLENE-CONNECTED QUINOLINYL MODULATORS OF ROR-GAMMA-T

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专利权人:

Janssen Pharmaceutica NV

发明人:

LEONARD, Kristi, A.,BARBAY, Kent,EDWARDS, James, P.,KREUTTER, Kevin, D.,KUMMER, David, A.,MAHAROOF, Umar,NISHIMURA, Rachel,URBANSKI, Maud,VENKATESAN, Hariharan,WANG, Aihua,WOLIN, Ronald, L.,WOODS, Cra

申请号：

DK13786564

公开号：

DK2909192T3

申请日:

2013.10.15

申请国别(地区):

DK

年份:

2017

代理人:

摘要：

The present invention comprises compounds of Formula I. wherein: R1, R2, R3, R4, R5, R6, R7, R8, and R9 are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating ROR&gamma；t activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim 1.

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