Musc Foundation for Research Development;Department Of Veterans Affairs
发明人:
TOMLINSON, Stephen,ATKINSON, Carl,YU, Xue-Zhong
申请号：
EP17861530
公开号：
EP3526249A4
申请日:
2017.10.17
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
Described herein are compositions and methods for treating or preventing an injury associated with transplant. Specifically, the disclosure provides a composition for treating or preventing an injury associated with transplantation, comprising (a) a targeted inhibitor molecule wherein the targeted inhibitor molecule comprises a targeting portion and an inhibitor portion, wherein the molecule inhibits complement pathways, and (b) a sub-therapeutic dose of an immunosuppressant agent. Further provided are methods of treating or preventing an injury associated with transplantation with activated complement by using the compositions.
