A minimally invasive medical sensor assembly with a conductor interface is provided. The medical sensor assembly includes a medical sensor element disposed at a distal portion, a control circuit electrically coupled to the medical sensor element, and a conductor interface disposed at a proximal portion. The conductor interface can include a plurality of channels and a removable member. In one embodiment, the medical sensor assembly is an ultrasound scanner assembly for an intravascular ultrasound (IVUS) device. An ultrasound scanner assembly and a method of manufacturing an IVUS device are also provided. Further, an IVUS device is provided. The IVUS device can include an ultrasound scanner assembly having a conductor interface disposed at a proximal portion. The IVUS device can include a cable having a connector at a distal portion. The connector can be configured to mechanically engage the conductor interface to electrically couple the ultrasound scanner assembly and another component.