Methods for conveying Fusarium oxysporum f.sp. melonis (FOM) race 1,2 resistance into non-resistant melon germplasm are provided. In some embodiments, the methods include introgressing FOM race 1,2 resistance into a non-resistant melon using one or more nucleic acid markers for marker-assisted selection among melon lines to be used in a melon breeding program, wherein the markers are linked to FOM race 1,2 resistance. Also provided are quantitative trait loci (QTLs) associated with resistance to FOM race 1,2； isolated and purified genetic markers associated with FOM race 1,2 resistance； melon plants, seeds, and tissue cultures produced by any of the disclosed methods； fruit and seed produced by the disclosed melon plants； and compositions including amplification primer pairs capable of initiating DNA polymerization by a DNA polymerase on melon nucleic acid templates to generate melon marker amplicons.
