This creation is about a replaceable anti fatigue pad structure, which includes the base and the surface. The upper surface of the base has a concave area, and the surface is assembled in the concave area, and the peripheral side of the base is inclined. Through the structure of laying the surface in the concave area of the base, the user can change the surface as required to meet the different needs of many users.本創作係有關於一種可更換式抗疲勞墊結構,係包括底座與表層,底座上表面具有凹陷區,於凹陷區中組設表層,且底座的周側面為具有傾斜度的斜面;俾透過在底座之凹陷區中鋪設表層的架構,令使用者可視需求更換表層,以符合眾多使用者的不同需求。