MEMORIAL SLOAN-KETTERING CANCER CENTER;VASCULAR BIOGENICS, LTD.
发明人:
KOLESNICK, RICHARD N.,STANCEVIC, BRANKA,SADELAIN, MICHEL,FUKS, ZVI,VARDA-BLOOM, NIRA,HARATS, DROR
申请号：
CA2783010
公开号：
CA2783010C
申请日:
2010.12.07
申请国别(地区):
CA
年份:
2020
代理人:
摘要：
Disclosed herein are methods and compositions for treating cancer by increasing radiation-induced damage to cancer without increasing radiation-induced side effects by increasing secretory ASMase levels specifically in tumor endothelium, and inducing apoptosis of tumor endothelial cells by treating the tumor with radiation. ASMase levels are increased in tumor endothelium by administration of a recombinant DNA construct comprising a region coding for a functional ASMase linked to particular transcriptional regulatory sequences that confer tissue-specific expression of ASMase.
