Pyrazole Derivatives, Cyclic Ether compounds - 4 - il - heterociclil - carboxamide, as inhibitors of the kinase PIM； Pharmaceutical composition that comprises； and its use for the treatment of cancer, immune disorders, cardiovascular diseases, viral infection, inflammation, Disturbed me Tabolismo / endocrine and neurological disorders.
Cyclic ether pyrazol-4-yl-heterocyclyl-carboxamide compounds of Formula I, including stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, wherein R2 is a cyclic ether and X is thiazolyl, pyrazinyl, pyridinyl, or pyrimidinyl, are useful for inhibiting Pim kinase, and for treating disorders such as cancer mediated by Pim kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.<；p>；LA SOLICITUD SE REFIERE A COMPUESTOS DERIVADOS DE 5-AMINO-N-(1H-PIRAZOL-4-IL)-TIAZOL-4-CARBOXAMIDA, INHIBIDORES DE QUINASA PIM, A UNA COMPOSICION FARMACEUTICA QUE LOS COMPRENDE Y A SU USO EN EL TRATAMIENTO DE ENFERMEDADES INMUNOLOGICAS, CARDIOVASCULARES, VIRICAS, METABOLICAS, CANCER, ENTRE OTRAS.<；/p>；
