Kit Oleg Ivanovich,Кит Олег Иванович,Menshenina Anna Petrovna,Меньшенина Анна Петровна,Moiseenko Tatyana Ivanovna,Моисеенко Татьяна Ивановна,Frantsiyants Elena Mikhajlovna,Франциянц Елена Михайловна,U
申请号：
RU2017119860
公开号：
RU0002648642C1
申请日:
2017.06.06
申请国别(地区):
RU
年份:
2018
代理人:
摘要：
FIELD: medicine.SUBSTANCE: invention relates to medicine, in particular oncology, and can be used to treat patients with invasive and locally advanced cervical cancer. Method includes the combination of plasmapheresis with neoadjuvant chemotherapy and immunotherapy. Before the start of chemotherapy, a gravitational discrete plasmapheresis session is performed with the MCS+ “Gemonetics” device in the PPP protocol mode with a perfusion speed of 40 ml/min and the rate of blood separation V=4,800 rpm, the volume of plasma extraction is 600–800 ml, as solutions of hydroxyethyl starch 10 % are injected intravenously as plasma substitution solutions, albumin 5 %, crystalloid solution, after 4–5 hours after the end of the plasmapheresis session, 1 ml of “Allokin-alpha” is injected subcutaneously. On day 3 of the treatment intravenously, cisplatin is administered dropwise at a dose of 75 mg/m2 against a background of hyperhydration, forced diuresis, under the cover of antiemetics, intravenously stream bleomycetin 20 mg/m2 and 1 ml of “Allokin-alpha” is injected subcutaneously. On the 5th day of treatment iv bleomycetin is injected intravenously at a dose of 20 mg/m2, 1 ml of “Allokin-alpha” is injected subcutaneously, at 7, 9, 11 days of treatment, 1 ml of “Allokin-alpha” is administered.EFFECT: use of the invention allows to shorten the duration of neoadjuvant treatment, reduce the number of necessary cycles of preoperative therapy by directly affecting the virus-induced tumor cells, overcoming the resistance of the tumor to cytostatics, achieving a more rapid clinical effect in the form of regression of the primary tumor focus, ensure synergism and prolongation of the activity of anti-stress protection mechanisms, increase antitumor resistance and activate immune defense of the organism.1 cl, 1 exИзобретение относится к медицине, в частности онкологии, и может быть использовано для лечения больных инвазивным и местно-распространенным раком шейки матки. Способ включает соче
