DÉRIVÉS DE 1,3-DIHYDROIMIDAZOLE-2-THIONE UTILISABLES DANS LE TRAITEMENT DE L'HYPERTENSION ARTÉRIELLE PULMONAIRE ET DES LÉSIONS PULMONAIRES

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专利权人:

BIAL - Portela & CA.; S.A.

发明人:

申请号：

EP13803292.5

公开号：

EP2919780B1

申请日:

2013.11.14

申请国别(地区):

EP

年份:

2018

代理人:

摘要：

The present invention relates to compounds of formula I: for use in treating pulmonary arterial hypertension and associated conditions, where R1, R2 and R3 are the same or different and signify hydrogens, halogens, alkyl, alkylaryl, alkyloxy, hydroxy, nitro, amino, alkylcarbonylamino, alkylamino or dialkylamino group； R4 signifies hydrogen, alkyl, -alkylaryl or -alkylheteroaryl； X signifies CH2, oxygen atom or sulphur atom； n is 1, 2 or 3, with the proviso that when n is 1, X is not CH2； and the individual (R)- and (S)-enantiomers or mixtures of enantiomers and pharmaceutically acceptable salts thereof.

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