A heart valve prosthesis device includes a tubular stent body having an inflow end and an outflow end； a leaflet disposed in the lumen of the stent body； and fixing structures connected with the stent body and configured to fix the leaflet on the stent body. The leaflet includes at least two halves, and a connecting portion(s) connecting two adjacent halves. The fixing structure includes a closed hollow portion located on the stent body, and a fixing rod disposed in the hollow portion； one end of the fixing rod is connected to the hollow portion, and the other end is a free end； the connecting portion is hung on the fixing rod from the free end so as to fix the leaflet on the stent body.
