University of Utah Research Foundation;Ramot at Tel-Aviv University Ltd.
发明人:
RONIT SATCHI-FAINARO,EHUD SEGAL,JINDRICH KOPECEK,PAVLA KOPECKOVA,HUAIZHONG PAN
申请号：
US14242901
公开号：
US20140212357A1
申请日:
2014.04.02
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Conjugates of hydroxypropyl methacrylamide (HPMA)-derived copolymers having attached thereto TNP-470 and a high load (e.g., higher than 3 mol %) of alendronate (ALN), and processes of preparing same are disclosed.Conjugates of polymers or copolymers having attached thereto an anti-angiogenesis agent and an oligoaspartate bone targeting agent, and processes of preparing same, are further disclosed.Pharmaceutical compositions containing these conjugates and uses thereof in the treatment and monitoring of bone related disorders are also disclosed.
