Centre National de la Recherche Scientifique - CNRS;Institut National de la Sante et de la Recherche Medicale (INSERM);Universidad de Navarra;Universite de la Mediterranee - Aix-Marseille II
The invention relates to Gram-negative bacteria carrying an inactivated gene encoding a glycosyltransferase involved in the synthesis of the core of the LPS of said Gram-negative bacteria, wherein said inactivated gene results in the synthesis of a LPS having a modified core. These strains have an attenuated virulence but induce a humoral immunity sufficient for ensuring vaccination of the host.
