PARK, Sung Hee,KIM, Seung Su,LIM, Hyung Kyu,CHOI, Jae Hyuk,CHOI, In Young,KWON, Se Chang
申请号：
EP15802343
公开号：
EP3152236A4
申请日:
2015.06.05
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
The present invention relates to a method for increasing serum half-life of a protein or peptide and decreasing immunogenicity thereof by site-specifically binding a carrier to a protein or peptide, and to the use thereof. The conjugate of the physiologically active protein or peptide of the present invention can significantly decrease immunogenicity in the human body and thus reduce antibody production rate against the protein or peptide. Therefore, the present conjugate has advantages in that a phenomenon of reduced clinical effects of the physiologically active protein or peptide is low, and it can be effectively used in the development of long-acting formulations having a high safety against the immune response.
