A multi-component formulation for the treatment, delay, and/or prevention of cognitive decline, including Alzheimers disease, and/or other neurodegenerative diseases. One embodiment of the multi-component formulation comprises methylsulfonylmethane, at least one energy source component, and at least one of an herbal component or a nutritional component. In one formulation, the energy source component is fructose 1,6-disphosphate. An herbal component of at least one formulation is curcumin. In one further formulation, a nutritional component is selected from the group consisting of docosahexaenoic acid, resveratrol, and blueberry.
