Black, Judith Lee,Burgess, Janette Kay,Oliver, Brian Gregory George,Weckmann, Markus
申请号：
AU2010258089
公开号：
AU2010258089A1
申请日:
2010.06.09
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The present invention relates to methods for inhibiting proliferation and/or migration of lymphatic endothelial cells and for inhibiting lymphangiogenesis, comprising administering to a subject, or to lymphatic endothelial cells derived therefrom, an effective amount of a collagen type IV-derived NC1 domain polypeptide or a fragment, derivative or variant thereof, a polynucleotide encoding the same, or an agent capable of increasing the expression or production of the NC1 domain polypeptide. Also provided are methods for the treatment or prevention of diseases and conditions associated with aberrant lymphatic endothelial cell activity.
